On February 21, 2020, leaders from all five of the McDonnell Initiative working groups convened at the Alexander Hotel in downtown Indianapolis, IN to discuss continued collaborations and projects. Specific areas of focus included stimulating interdisciplinary thinking and work between the Ecosystems and Microbial Regeneration groups, and planning for the upcoming History of Biology Summer Seminar in Woods Hole (“Regeneration Again,” 13-20 May 2020).